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Pharmaceuticals released from senior residences: occurrence and risk evaluation

Lacorte, Silvia and Luis, Silvia and Gómez-Canela, Cristian and Sala-Comorera, Teresa and Courtier, Audrey and Roig, Benoit and Oliveira-Brett, Ana Maria and Joannis-Cassan, Claire and Aragonés, Juan Ignacio and Poggio, Lucia and Noguer, Thierry and Lima, Luisa and Barata, Carlos and Calas-Blanchard, Carole Pharmaceuticals released from senior residences: occurrence and risk evaluation. (2018) Environmental Science and Pollution Research, 25 (7). 6095-6106. ISSN 0944-1344

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Official URL: https://doi.org/10.1007/s11356-017-9755-1

Abstract

One of the main pursuits, yet most difficult, in monitoring studies is to identify the sources of environmental pollution. In this study, we have identified health-care facilities from south European countries as an important source of pharmaceuticals in the environment. We have estimated that compounds consumed in by the elderly and released from effluents of senior residences can reach river waters at a concentration higher than 0.01 μg/L, which is the European Medicines Agency (EMA) threshold for risk evaluation of pharmaceuticals in surface waters. This study has been based on five health institutions in Portugal, Spain, and France, with 52 to 130 beds. We have compiled the pharmaceuticals dispensed on a daily base and calculated the consumption rates. From 54.9 to 1801 g of pharmaceuticals are consumed daily, with laxatives, analgesics, antiepileptics, antibiotics, and antidiabetic agents being the main drug families administered. According to excretion rates, dilution in the sewerage system, and elimination in wastewater treatment plants, macrogol, metformin, paracetamol, acetylcysteine, amoxicillin, and gabapentin, among others, are expected to reach river waters. Finally, we discuss the risk management actions related to the discharge of pharmaceuticals from senior residences to surface waters.

Item Type:Article
HAL Id:hal-01770538
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Consejo Superior de Investigaciones Científicas - CSIC (SPAIN)
Other partners > Universidade de Coimbra (PORTUGAL)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Other partners > Instituto Universitario de Lisboa - ISCTE IUL (PORTUGAL)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Universidad Complutense de Madrid - UCM (SPAIN)
Other partners > Université de Nîmes (FRANCE)
Other partners > Université de Perpignan Via Domitia - UPVD (FRANCE)
Laboratory name:
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Deposited By: Loetitia MOYA
Deposited On:15 Jan 2019 08:50

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