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Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates

Dréno, Brigitte and Pécastaings, Sophie and Corvec, Stéphane and Veraldi, Stefano and Khammari, Amir and Roques, Christine Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. (2018) Journal of the European Academy of Dermatology and Venereology, 32. 5-14. ISSN 0926-9959

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Official URL: https://doi.org/10.1111/jdv.15043

Abstract

While the commensal bacterium Propionibacterium acnes (P. acnes) is involved in the maintenance of a healthy skin, it can also act as an opportunistic pathogen in acne vulgaris. The latest findings on P. acnes shed light on the critical role of a tight equilibrium between members of its phylotypes and within the skin microbiota in the development of this skin disease. Indeed, contrary to what was previously thought, proliferation of P. acnes is not the trigger of acne as patients with acne do not harbour more P. acnes in follicles than normal individuals. Instead, the loss of the skin microbial diversity together with the activation of the innate immunity might lead to this chronic inflammatory condition. This review provides results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of P. acnes renamed Cutibacterium acnes (C. acnes), and to the better characterisation of its phylogenetic cluster groups. Moreover, the latest data on the role of C. acnes and its different phylotypes in acne are presented, providing an overview of the factors that could participate in the virulence and in the antimicrobial resistance of acne-associated strains. Overall, this emerging key information offers new perspectives in the treatment of acne, with future innovative strategies focusing on C. acnes biofilms and/or on its acne-associated phylotypes.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Centre Hospitalier Universitaire de Nantes - CHU Nantes (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Other partners > Istituto di Ricovero e Cura a Carattere Scientifico - IRCCS (ITALY)
Other partners > Ospedale Maggiore de Milan (ITALY)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Università degli Studi di Milano (ITALY)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
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Deposited By: Loetitia MOYA
Deposited On:14 Jan 2019 10:40

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