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HLADH-catalyzed synthesis of β-amino acids, assisted by continuous electrochemical regeneration of NAD+ in a filter press microreactor

Rodríguez-Hinestroza, Rossmery A. and López, Carmen and López-Santín, Josep and Kane, Cheikhou and Dolors Benaiges, M. and Tzedakis, Théo HLADH-catalyzed synthesis of β-amino acids, assisted by continuous electrochemical regeneration of NAD+ in a filter press microreactor. (2017) Chemical Engineering Science, 158. 196-207. ISSN 0009-2509

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Official URL: https://doi.org/10.1016/j.ces.2016.10.010

Abstract

This work focuses on the use of electrochemical microreactors, applied to the direct electroregeneration of nicotinamide dinucleotide (NAD+) used in-situ for the enzymatically-assisted oxidation of the β-alanine. Mechanistic and chemical/electrochemical reactor approaches were investigated, to achieve satisfactory conversions (>80%) of the substrate in reasonable (1–2 days) reaction times; no fouling observed of the gold anode. An original method was proposed to limit the complexation effect of the produced β-alanine to the enzyme. Simulations of the overall system were achieved and an estimation of the required kinetic and Michaelis constants was proposed.

Item Type:Article
HAL Id:hal-02134833
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Universitat Autònoma de Barcelona - UAB (SPAIN)
Other partners > Université Cheikh Anta Diop de Dakar - UCAD (SENEGAL)
Laboratory name:
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Deposited By: Loetitia MOYA
Deposited On:05 Oct 2018 08:26

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