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Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network. Part II: Flow variations induced by global or localized modifications of arteriolar diameters

Lorthois, Sylvie and Cassot, Francis and Lauwers, Frédéric Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network. Part II: Flow variations induced by global or localized modifications of arteriolar diameters. (2011) NeuroImage, 54 (4). 2840-2853. ISSN 1053-8119

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Official URL: https://doi.org/10.1016/j.neuroimage.2010.10.040

Abstract

In a companion paper (Lorthois et al., Neuroimage, inpress),we perform the first simulations of blood flow in an anatomically accurate large human intra-cortical vascular network (~10000 segments), using a 1D non-linear model taking into account the complex rheological properties of blood flow in microcirculation. This model predicts blood pressure, blood flow and hematocrit distributions, volumes of functional vascular territories, regional flow at voxel and network scales, etc. Using the same approach, we study flow reorganizations induced by global arteriolar vasodilations (an isometabolic global increase in cerebral blood flow). For small to moderate global vasodilations, the relationship between changes in volume and changes in flowis in close agreement with Grubb's law, providing a quantitative tool for studying the variations of its exponent with underlying vascular architecture. A significant correlation between blood flow and vascular structure at the voxel scale, practically unchanged with respect to baseline, is demonstrated. Furthermore, the effects of localized arteriolar vasodilations, representative of a local increase in metabolic demand, are analyzed. In particular, localized vasodilations induce flowchanges, including vascular steal, in the neighboring arteriolar trunks at small distances (< 300 μm), while their influence in the neighboring veins is much larger (about 1 mm), which provides an estimate of the vascular point spread function.More generally, for the first time, the hemodynamic component of various functional neuroimaging techniques has been isolated from metabolic and neuronal components, and a direct relationship with several known characteristics of the BOLD signal has been demonstrated.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at https://www.sciencedirect.com/science/article/pii/S1053811910013327
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Laboratory name:
Funders:
French Department of Education, Research and Technology - GDR CNRS 2760 “Biomécanique des fluides et des transferts: Interactions Fluide Structure Biologique”
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Deposited By: Sylvie LORTHOIS
Deposited On:14 Feb 2018 14:32

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