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Modelling the redox imbalance in Dominant Optic Atrophy: the case of respiratory Complex I

Merabet, Nadège and Bordeneuve-Guibé, Joël and Davezac, Noélie Modelling the redox imbalance in Dominant Optic Atrophy: the case of respiratory Complex I. (2017) In: IFAC World Congress 2017, 9 July 2017 - 14 July 2017 (Toulouse, France).

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Official URL: https://doi.org/10.1016/j.ifacol.2017.08.255

Abstract

Dominant Optic Atrophy is a neuro-ophthalmic disease characterized by the degeneration of the optic nerves. As other neurodegenerative diseases, this pathology was associated with dysfunctional mitochondrial respiratory complexes and an increased production of Reactive Oxygen Species (ROS). Our objective is to create a mathematical model of the molecular mechanisms involved in the pathogenesis of Dominant Optic Atrophy in order to predict their evolution and give appropriated treatment based on in-silico analysis with physiological parameters from a specific patient. The first part of the work presented here concerns processes and feedback mechanisms of the whole dysfunctional mitochondrial system. The behaviour of the system is explained with a block diagram. In the second part, we present a detailed stochastic model of catalytic activity and ROS production of respiratory complex I. We developed the model using a Petri net formalism and a continuous-time Markov chains theory. The simulations were realized on Matlab and compared to kinetic data from the literature. Our model is able to reproduce the dynamics of the complex I system and to simulate observed behaviours of this system regarding ROS production

Item Type:Conference or Workshop Item (Paper)
Additional Information:Thanks to Springer editor. The definitive version is available at https://www.sciencedirect.com/science/article/pii/S2405896317305682
HAL Id:hal-01690097
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Ecole Nationale de l'Aviation Civile - ENAC (FRANCE)
Université de Toulouse > Institut Supérieur de l'Aéronautique et de l'Espace - ISAE-SUPAERO (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
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Deposited By: joel bordeneuve-guibe
Deposited On:22 Jan 2018 15:00

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