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Freeze-casting for PLGA/carbonated apatite composite scaffolds: structure and properties

Schardosim, Mariane and Soulié, Jérémy and Poquillon, Dominique and Cazalbou, Sophie and Duployer, Benjamin and Tenailleau, Christophe and Rey, Christian and Hübler, Roberto and Combes, Christèle Freeze-casting for PLGA/carbonated apatite composite scaffolds: structure and properties. (2017) Materials Science and Engineering C, 77. 731-738. ISSN 0928-4931

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Official URL: http://dx.doi.org/10.1016/j.msec.2017.03.302

Abstract

This paper focuses on the fabrication of three-dimensional porous PLGA-biomimetic carbonated apatite composite scaffolds by freeze-casting and using dimethyl carbonate as a solvent. Several charge/polymer ratios were tested in order to finely understand the influence of the filler rate on the scaffold porosity and mechanical and degradation properties using complementary characterization techniques (SEM, mercury porosimetry and X-ray microtomography). It was demonstrated that the apatite ratio within the composite scaffold has a strong influence in terms of architecture, material cohesion, mechanical properties and in vitro degradation properties. An optimum biomimetic apatite ratio was reached to combine good mechanical properties (higher rigidity) and material cohesion. In vitro degradation studies showed that higher apatite filler rates limited PLGA degradation and enhanced the hydrophilicity of the scaffolds which is expected to improve the biological properties of the scaffolds in addition to the bioactivity related to the presence of the apatite analogous to bone mineral.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at : http://www.sciencedirect.com/science/article/pii/S0928493116327941
HAL Id:hal-01623713
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Pontificia Universidade Catolica do Rio Grande do Sul - PUCRS (BRAZIL)
Laboratory name:
Funders:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - FERMaT Midi-Pyrénées Federation FR3089
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Deposited By: Christele COMBES
Deposited On:25 Oct 2017 13:30

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