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Influence of growth modulation on the effective permeability of the vertebral end plate. A porcine experimental scoliosis model

Accadbled, Franck and Laffosse, Jean-Michel and Odent, Thierry and Gomez-Brouchet, Anne and Sales de Gauzy, Jérôme and Swider, Pascal Influence of growth modulation on the effective permeability of the vertebral end plate. A porcine experimental scoliosis model. (2011) Clinical Biomechanics, 26 (4). 337-342. ISSN 0268-0033

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Official URL: http://dx.doi.org/10.1016/j.clinbiomech.2010.11.007

Abstract

Background: Abnormal mechanical loading occurs in scoliosis as compared to normal spines. Intervertebral disc degeneration has been correlated with alteration of bone density in adjacent vertebral bodies. How vertebral end plate remodels in scoliosis and the consequences on disc homeostasis are not well understood. Permeability is a relevant physical measure to quantify mass transport in porous media. We hypothesized that effective permeability of the vertebral end plate was modified by growth modulation in a scoliosis animal model. Methods: Flexible asymmetric posterior instrumentation was undertaken on six healthy four-week-old pigs. Two sets of left pedicle screws were inserted and connected with a stainless steel cable. After two months, the apical intervertebral unit and three units located cranially and caudally, were harvested. One central and two lateral specimens were investigated using a previously validated method for measuring permeability. Findings: A three-dimensional deformity was obtained in all six animals with an average of 42 degrees right thoracic curve. 44 degrees lordosis and 21 degrees rotation. Permeability was significantly greater in the center of the end plates than in the periphery and it was decreased by -45% towards the apex of the deformity. Fluid flow direction did not play a significant role. No significant difference was found between the convex side and the concave side. Interpretation: The end plate is a crucial zone for diffusive and convective transport and we showed in a scoliosis animal model that a growth modulation may decrease its effective permeability. The proposed methodology and associated results could help to understand degenerative changes in human spine.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The original PDF of the article can be found at http://www.sciencedirect.com/science/article/pii/S0268003310003013
HAL Id:hal-01590827
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Other partners > Université Paris Descartes - Paris V (FRANCE)
Other partners > Institut d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement - VetAgro Sup (FRANCE)
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Deposited By: Pascal SWIDER
Deposited On:20 Sep 2017 11:23

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