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Adipose stromal cells improve healing of vocal fold scar: Morphological and functional evidences

De Bonnecaze, Guillaume and Chaput, Benoit and Woisard, Virginie and Uro-Coste, Emmanuelle and Swider, Pascal and Vergez, Sebastien and Serrano, Elie and Casteilla, Louis and Planat-Benard, Valerie Adipose stromal cells improve healing of vocal fold scar: Morphological and functional evidences. (2016) The Laryngoscope, 126 (8). E278-E285. ISSN 0023-852X

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Official URL: http://dx.doi.org/10.1002/lary.25867

Abstract

OBJECTIVES/HYPOTHESIS: Adipose derived stromal cells (ASCs) are abundant and easy to prepare. Such cells may be useful for treating severe vocal disturbance caused by acute vocal fold scars. STUDY DESIGN: Prospective animal experiments with controls. METHODS: Twenty New-Zealand white rabbits were used in the present study. We evaluated vocal fold healing, with or without injection of autologous ASCs, after acute scarring. A defined lesion was created and the ASCs were immediately injected. Vocal fold regeneration was evaluated histomorphometrically and via viscoelastic analysis using an electrodynamic shaker. RESULTS: Six weeks after ASC injection, vocal folds exhibited significantly less inflammation than control folds (P < 0.005). In addition, hypertrophy of the lamina propria and fibrosis were significantly reduced upon ASC injection (P < 0.02). The decrease in viscoelastic parameters was less important in the ASC injected group compared to the noninjected group (P = 0.08). CONCLUSION: Injection of autologous ASCs improved vocal fold healing in our preclinical model. Further studies are needed, but this method may be useful in humans. LEVEL OF EVIDENCE: NA. Laryngoscope, 126:E278-E285, 2016.

Item Type:Article
HAL Id:hal-01585568
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Etablissement Français du Sang - EFS Midi-Pyrénées (FRANCE)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
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Deposited By: Pascal SWIDER
Deposited On:11 Sep 2017 14:20

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