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BMI-related microstructural changes in the tibial subchondral trabecular bone of patients with knee osteoarthritis

Reina, Nicolas and Cavaignac, Etienne and Pailhe, Régis and Pailliser, Aymeric and Bonnevialle, Nicolas and Swider, Pascal and Laffosse, Jean-Michel BMI-related microstructural changes in the tibial subchondral trabecular bone of patients with knee osteoarthritis. (2017) Journal of Orthopaedic Research, vol. 35 (n° 8). pp. 1653-1660. ISSN 0736-0266

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Official URL: http://dx.doi.org/10.1002/jor.23459

Abstract

Overweight is a risk factor for osteoarthritis on the knees. Subchondral trabecular bone (SCTB) densification has been shown to be associated with cartilage degeneration. This study analyzed the microarchitectural changes in the SCTB of tibial plateaus to validate the hypothesis that the degree of remodeling is correlated with a patient's body weight. Twenty-one tibial plateaus were collected during total knee arthroplasty from 21 patients (15 women and 6 men). These patients had a mean age of 70.4 years (49-81), mean weight of 74.7 kg (57-93) and mean body mass index (BMI) of 28.4 kg/m2 (21.3-40.8). One cylindrical plug was harvested in the center of each tibial plateau (medial and lateral). Micro-CT parameters (7.4 μm resolution) were determined to describe the SCTB structure. On the medial plateau, there were significant correlations between BMI and bone volume fraction BV/TV (r = 0.595, p = 0.004), structure model index SMI (r = -0.704 p = 0.0002), trabecular space Tb.Sp (r = 0.600, p = 0.04) and trabecular number Tb.N (r = 0.549, p = 0.01). SCTB densification during osteoarthritis is associated with a reduction in its elastic modulus, which could increase cartilage stress, and accelerate cartilage loss. SCTB densification has been shown to precede cartilage degeneration. The correlation of SCTB microarchitecture and body weight may explain why knee osteoarthritis is more common in overweight or obese patients. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

Item Type:Article
Additional Information:Thanks to Wiley editor. The original PDF of the article can be found at http://onlinelibrary.wiley.com/doi/10.1002/jor.23459/full
HAL Id:hal-01585496
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Centre Hospitalier Universitaire Grenoble Alpes - CHU Grenoble Alpes (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Laboratory name:
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Deposited By: Pascal SWIDER
Deposited On:11 Sep 2017 13:40

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