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An assessment of methods of moments for the simulation of population dynamics in large-scale bioreactors

Pigou, Maxime and Morchain, Jérôme and Fede, Pascal and Penet, Marie-Isabelle and Laronze, Geoffrey An assessment of methods of moments for the simulation of population dynamics in large-scale bioreactors. (2017) Chemical Engineering Science, 171. 218-232. ISSN 0009-2509

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Official URL: http://dx.doi.org/10.1016/j.ces.2017.05.026

Abstract

A predictive modelling for the simulation of bioreactors must account for both the biological and hydrodynamics complexities. Population balance models (PBM) are the best approach to conjointly describe these complexities, by accounting for the adaptation of inner metabolism for microorganisms that travel in a large-scale heterogeneous bioreactor. While being accurate for solving the PBM, the Class and Monte-Carlo methods are expensive in terms of calculation and memory use. Here, we apply Methods of Moments to solve a population balance equation describing the dynamic adaptation of a biological population to its environment. The use of quadrature methods (Maximum Entropy, QMOM or EQMOM) is required for a good integration of the metabolic behavior over the population. We then compare the accuracy provided by these methods against the class method which serves as a reference. We found that the use of 5 moments to describe a distribution of growth-rate over the population gives satisfactory accuracy against a simulation with a hundred classes. Thus, all methods of moments allow a significant decrease of memory usage in simulations. In terms of stability, QMOM and EQMOM performed far better than the Maximum Entropy method. The much lower memory impact of the methods of moments offers promising perspectives for the coupling of biological models with a fine hydrodynamics depiction.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at : http://www.sciencedirect.com/science/article/pii/S0009250917303391
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Institut National des Sciences Appliquées de Toulouse - INSA (FRANCE)
Other partners > Sanofi Aventis (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Laboratory name:
Funders:
Sanofi Chimie - C&BD Biochemistry Vitry
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Deposited By: Pascal FEDE
Deposited On:09 Jun 2017 07:16

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