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Inflammatory response to naturally occuring tiger snake envenomation in dogs, with a special emphasis on il-6

Costet, Juliette. Inflammatory response to naturally occuring tiger snake envenomation in dogs, with a special emphasis on il-6. Thèse d'exercice, Médecine vétérinaire, Ecole Nationale Vétérinaire de Toulouse - ENVT, 2016, 110 p.

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Abstract

Tiger snakes are the most common snake species implicated in dogs’ snake envenomation in Australia. Clinical signs, biochemical and haematological parameters have been studied but the systemic inflammatory response to snakebite in dogs is poorly documented. Antivenom administration could further trigger a venom induced inflammatory response. Ten dogs presented at the University of Melbourne Veterinary Hospital (UMVH) for snake envenomation were enrolled in the study. Clinical signs, snakebite data and clinicopathological parameters were recorded. An inflammatory marker, interleukin-6 (IL-6), was determined in dog plasma at different times after admission. Snakebite caused mild clinical and biochemical signs and variable degrees of coagulopathy. IL-6 was indictable for all control cases. For the affected dogs, IL-6 levels widely ranges from 0 pg/mL to 260 pg/mL. IL-6 concentration was markedly influenced by time and was significantly increased after antivenom administration. A systemic inflammatory response naturally occurs in dogs envenomed by tiger snake, possibly exacerbated by antivenom administration. Further clinical research including a larger population and additional inflammatory markers is warranted to better understand the inflammatory response to snakebite in dogs and to consider new therapeutic avenue.

Item Type:Thèse d'exercice
Uncontrolled Keywords:
Institution:Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Research Director:
Boullier, Séverine
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Deposited By: Karine Hernandez
Deposited On:16 Feb 2017 13:15

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