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Structural and hemodynamic comparison of synthetic and anatomical cerebral capillary networks

Smith, Amy and Larue, Anne and Peyrounette, Myriam and Lorthois, Sylvie Structural and hemodynamic comparison of synthetic and anatomical cerebral capillary networks. (2016) In: 22nd Congress of the European Society of Biomechanics, 10 July 2016 - 13 July 2016 (Lyon, France). (Unpublished)

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Abstract

A method for developing 3D synthetic capillary networks representative of the geometric, topological and functional properties of the cerebral microcirculation is presented. Previous methods [2, 4] have lacked quantitative comparison against anatomical cerebral networks. It is hypothesised that healthy capillary networks are space-filling, ensuring that the maximum separation of each tissue cell from the nearest vessel is less than a certain length, linked to the diffusion limited distance of oxygen transport in oxygen consuming tissue. Building on this theory, Lorthois & Cassot [3] constructed 2D synthetic space-filling networks by randomly placing one point in each cell of an n × n grid. From this set of points, representing the centres of tissue cells, Voronoi diagrams were extracted with the edges producing a 2D network of capillaries with three segments at each node, a characteristic feature of cerebral capillaries networks (see Figure 1, left). The goal of the present work is to extend this approach to 3D and to compare the resulting structural and hemodynamic properties to the properties of anatomical cerebral capillary networks.

Item Type:Conference or Workshop Item (Speech)
Additional Information:Thanks to 22nd Congress of the European Society of Biomechanics : https://esbiomech.org/conference/index.php/congress/lyon2016/
Audience (conference):International conference without published proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
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Deposited By: Sylvie LORTHOIS
Deposited On:08 Dec 2016 12:34

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