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Investigations of Saccharothrix algeriensis Growth on Synthetic Media

Strub, Caroline and Brandam , Cédric and Meyer, Xuan Mi and Lebrihi, Ahmed Investigations of Saccharothrix algeriensis Growth on Synthetic Media. (2008) Journal of Bioscience and Bioengineering, vol. 1 (n° 1). pp. 111-113.

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Official URL: http://dx.doi.org/10.1263/jbb.106.111

Abstract

Development of bacterial resistance to antibiotics has lead to investigations of rare bacteria, which produce new bioactive molecules. Saccharothrix algriensis has been isolated from the desert Maghreb. It produces dithiolopyrrolones, some of which were newly identified. In order to optimize and control production of dithiolopyrrolones, investigation regarding microorganism metabolism was required. Growth on semisynthetic medium containing 2 g⋅ l–1 of yeast extract was complicated because it was performed on several substrates. Moreover, because development of this bacterium on minimum medium was difficult, its composition was optimized by screening of different compounds led by yeast extract. Uracil added to the minimum medium allowed a maximum biomass production of 1.35 g⋅ l–1 compared to 0.32 g⋅ l–1 without uracil. Moreover, nonpolar amino acids and trace metal elements stimulated Saccharothrix algeriensis growth.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Bioprocédés et systèmes microbiens (BioSyM)
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Procédés Systèmes Industriels (PSI) - Analyse fonctionnelle des Procédés
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Deposited By: Hélène Dubernard
Deposited On:20 Nov 2008 11:41

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