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Prediction of the acoustic and bubble fields in insonified freeze-drying vials

Louisnard, Olivier and Cogné, Claudia and Labouret, Stéphane and Montes-Quiroz, William and Peczalski, Roman and Baillon, Fabien and Espitalier, Fabienne Prediction of the acoustic and bubble fields in insonified freeze-drying vials. (2015) Ultrasonics Sonochemistry, 26. 186-192. ISSN 1350-4177

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Official URL: http://dx.doi.org/10.1016/j.ultsonch.2015.03.008

Abstract

The acoustic field and the location of cavitation bubble are computed in vials used for freeze-drying, insonified from the bottom by a vibrating plate. The calculations rely on a nonlinear model of sound propagation in a cavitating liquid [Louisnard, Ultrason. Sonochem., 19, (2012) 56-65]. Both the vibration amplitude and the liquid level in the vial are parametrically varied. For low liquid levels, a threshold amplitude is required to form a cavitation zone at the bottom of the vial. For increasing vibration amplitudes, the bubble field slightly thickens but remains at the vial bottom, and the acoustic field saturates, which cannot be captured by linear acoustics. On the other hand, increasing the liquid level may promote the formation of a secondary bubble structure near the glass wall, a few centimeters below the free liquid surface. These predictions suggest that rather complex acoustic fields and bubble structures can arise even in such small volumes. As the acoustic and bubble fields govern ice nucleation during the freezing step, the final crystal’s size distribution in the frozen product may crucially depend on the liquid level in the vial.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Ultrasonics Sonochemistry website : http://www.sciencedirect.com/science/article/pii/S135041771500070X
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Ecole nationale supérieure des Mines d'Albi-Carmaux - IMT Mines Albi (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Université Claude Bernard-Lyon I - UCBL (FRANCE)
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Agence Nationale pour la Recherche
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Deposited By: Olivier LOUISNARD
Deposited On:12 Sep 2016 11:37

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