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3D computations of mucociliary clearance

Chatelin, Robin and Anne-Archard, Dominique and Poncet, Philippe 3D computations of mucociliary clearance. (2016) In: European Congress on Computational Methods in Applied Sciences and Engineering - ECCOMAS 2016, 5 June 2016 - 10 June 2016 (Hersonissos, Crete, Greece).

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Abstract

In this talk, an overview of the results obtained in the ANR project BioFiReaDy will be presented. This interdisciplinary project aims at understanding mucociliary clearance: the natural flow of mucus in the lung, which protects bronchus from inhaled agents such as dust, pathogens or pollution particles... 3D simulations are used, as well as experimental rheology to characterize the non-Newtonian rheological behaviour of this complex biological fluid. Using suitable numerical algorithms specially developed to compute this 3D fluid-structure interaction (FSI) problem (mucus is propelled by beating cilia), it is now possible to study the biological parameters influence on the mucus flow. These algorithms are based on (i) a novative projection method which integrates the resolution of rheological shear-thinning effects, (ii) a penalization techniques coupled to a Shermann--Morrison--Woodbury approach to compute the FSI, (iii) the use of fast solvers (FFT or multigrid) and (iv) a lagrangian discretization of the convection effects. These numerical methods are particularly suitable for 3D computations since the global computational cost is linear with respect to the number of grid points, which is very interesting for a parametric study. Several results will be presented, in particular for pathological situations such as cystic fibrosis.

Item Type:Conference or Workshop Item (Speech)
Additional Information:No full-text document attached to this repository. Thanks to the European Community on Computational Methods in Applied Sciences (ECCOMAS). This abstract is available at : https://www.eccomas2016.org/proceedings
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Ecole Nationale d'Ingénieurs de Saint Etienne - ENISE (FRANCE)
Other partners > Ecole Nationale des Travaux Publics de l'Etat - ENTPE (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Ecole Centrale de Lyon (FRANCE)
Other partners > Université de Pau et des Pays de l'Adour - UPPA (FRANCE)
Laboratory name:
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Deposited By: Dominique ANNE ARCHARD
Deposited On:21 Jul 2016 14:26

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