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Production, by co-grinding in a media mill, of porous biodegradable polylactic acid-apatite composite materials for bone tissue engineering

Le Bolay, Nadine and Santran, Véronique and Dechambre, Gérard and Combes, Christèle and Drouet, Christophe and Lamure, Alain and Rey, Christian Production, by co-grinding in a media mill, of porous biodegradable polylactic acid-apatite composite materials for bone tissue engineering. (2009) Powder Technology, vol. 1 . pp. 89-94. ISSN 0032-5910

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Official URL: http://dx.doi.org/10.1016/j.powtec.2008.04.043

Abstract

This paper presents the results of a study of the production of porous biodegradable composite materials by co-grinding, followed by scaffolding. Dry powders of polylactic acid and nanocrystalline carbonated apatite, analogous to bone mineral were co-ground in a tumbling ball mill in order to disperse the mineral filler within the polymer. Porous scaffolds were then made by hot moulding the mixture of the two components along with a pore-forming agent which was subsequently eliminated by washing. The mechanical resistance of the scaffolds was evaluated in order to determine the best operating conditions to produce implants offering optimised properties for use as bone substitutes. It was shown that 30 wt.% of filler and 70 wt.% of pore-forming agent produce scaffolds which are sufficiently porous and resistant

Item Type:Article
Additional Information: Article in press Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Powder Technology website : http://www.sciencedirect.com/science/journal/00325910
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
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Deposited By: Hélène Dubernard
Deposited On:17 Nov 2008 10:08

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