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Flow distributions and spatial correlations in human brain capillary networks

Lorthois, Sylvie and Peyrounette, Myriam and Larue, Anne and Le Borgne, Tanguy Flow distributions and spatial correlations in human brain capillary networks. (2015) In: 68th Annual Meeting of the APS Division of Fluid Dynamics, 22 November 2015 - 24 November 2015 (Boston, United States). (Unpublished)

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Abstract

The vascular system of the human brain cortex is composed of a space filling mesh-like capillary network connected upstream and downstream to branched quasi-fractal arterioles and venules. The distribution of blood flow rates in these networks may affect the efficiency of oxygen transfer processes. Here, we investigate the distribution and correlation properties of blood flow velocities from numerical simulations in large 3D human intra-cortical vascular network ( 10000 segments) obtained from an anatomical database. In each segment, flow is solved from a 1D non-linear model taking account of the complex rheological properties of blood flow in microcirculation to deduce blood pressure, blood flow and red blood cell volume fraction distributions throughout the network. The network structural complexity is found to impart broad and spatially correlated Lagrangian velocity distributions, leading to power law transit time distributions. The origins of this behavior (existence of velocity correlations in capillary networks, influence of the coupling with the feeding arterioles and draining veins, topological disorder, complex blood rheology) are studied by comparison with results obtained in various model capillary networks of controlled disorder.

Item Type:Conference or Workshop Item (Poster)
Audience (conference):International conference without published proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Université de Rennes 1 (FRANCE)
Laboratory name:
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Deposited By: Sylvie LORTHOIS
Deposited On:12 Jan 2016 10:36

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