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Optimized spectral clustering for segmentation of dynamic PET images

Zbib, Hiba and Mouysset, Sandrine and Stute, Simon and Girault, Jean-Marc and Charara, Jamal and Chalon, Sylvie and Galineau, Laurent and Buvat, Irène and Tauber, Clovis Optimized spectral clustering for segmentation of dynamic PET images. (2013) In: 2nd International Conference on Advances in Biomedical Engineering (ICABME 2013), 11 September 2013 - 13 September 2013 (Tripoli, Lebanon).

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Official URL: http://dx.doi.org/10.1109/ICABME.2013.6648837

Abstract

he quantification of dynamic PET images requires the definition of regions of interest. The manual delineation is a time consuming and unreproducible process due to the poor resolution of PET images. Approaches were proposed in the literature to classify the kinetic profiles of voxels, however, they are generally either sensitive to initial conditions or favor convex shaped clusters. Recently we have proposed a kinetic spectral clustering (KSC) method for segmentation of dynamic PET images that has the advantage of handling clusters with arbitrary shape in the space in which they are identified. However, its use for clinical applications is still hindered by the manual setting of several parameters. In this paper, we propose an extension of KSC to make it automatic (ASC). A new unsupervised clustering criterion is tailored and a global optimization by a probabilistic metaheuristic algorithm is used to select the scale parameter and the weighting factors involved in the method. We validate our approach with GATE Monte Carlo simulations. Results obtained with ASC compare closely with those obtained with optimal manual parameterization of KSC, and outperform those obtained with two other approaches from the literature.

Item Type:Conference or Workshop Item (Paper)
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Other partners > Lebanese University - LU (LEBANON)
Other partners > Université de Paris Diderot - Paris 7 (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
Other partners > Centre Hospitalier Régional Universitaire de Tours - CHU Tours (FRANCE)
Other partners > Université François-Rabelais de Tours (FRANCE)
Other partners > Université Paris-Sud 11 (FRANCE)
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Deposited By: IRIT IRIT
Deposited On:27 Apr 2015 09:23

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