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Balkan endemic nephropathy: Role of ochratoxins A through biomarkers

Castegnaro, Marcel and Canadas, Delphine and Vrabcheva, Terry and Petkova- Bocharova, Theodora and Chernozemsky, Ivan N and Pfohl-Leszkowicz, Annie Balkan endemic nephropathy: Role of ochratoxins A through biomarkers. (2006) Molecular Nutrition & Food Research, vol. 5 (n° 6). pp. 519-529. ISSN 1613-4133

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Official URL: http://dx.doi.org/10.1002/mnfr.200500182

Abstract

Several studies implicated mycotoxins, in endemic kidney disease geographically limited to Balkan region (Balkan endemic nephropathy (BEN)). In Bulgaria, much higher prevalence of ochratoxin A (OTA), exceeding 2 lg/L, was observed in the blood of affected population. OTA is found more often in the urine of people living in BEN-endemic villages. To confirm and quantify exposure to OTA in Vratza district, we followed up OTA intake for 1 month, OTA in blood and urine from healthy (20–30 years old) volunteers, from two villages with high risk for BEN disease. Food samples were collected daily, blood and urine at the beginning of each week. Relations between increasing OTA intake,blood concentration and elimination of OTA in urine have been studied in rats. Average weekly intake of OTA varies from 1.9 to 206 ng/kg body weight, twice tolerable weekly intake recommended by JECFA. OTA blood concentrations are in the same range as previously reported in this region with concentrations reaching 10 lg/L. Weekly OTA food intake is not directly correlated with blood and urine concentrations. Biomarkers of biological effects such as DNA adducts were detected in patients affected by urinary tract tumours (UTT) and in rat study. All these plead for the implication of OTA,in BEN and UTT.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Other partners > National Oncology Center of Sofia - NOC (BULGARIA)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > National Center of Hygiene, Medical Ecology and Nutrition - NCHMEN (BULGARIA)
Other partners > International Agency for Research on Cancer - IARC (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
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Deposited By:Hélène Dubernard

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