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Influence of solvent choice on the optimisation of a reaction–separation operation : application to a Beckmann rearrangement reaction

Elgue, Sébastien and Prat, Laurent E. and Cognet, Patrick and Cabassud, Michel and Le Lann, Jean-Marc and Cezerac, Jérome Influence of solvent choice on the optimisation of a reaction–separation operation : application to a Beckmann rearrangement reaction. (2004) Separation and Purification Technology, vol. 3 (n° 1-3). pp. 273-281. ISSN 1383-5866

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Official URL: http://dx.doi.org/10.1016/S1383-5866(03)00200-4

Abstract

In pharmaceutical syntheses, the solvent choice generally represents a complex design step. Traditionally, this choice is operated according to criteria connected with the reaction step and without any consideration on the following separation steps. The purpose of this study is to highlight the benefits of a global approach of optimisation for the solvent determination. In this way, an optimisation framework dedicated to global synthesis is applied to a simple reaction–separation operation integrating a Beckmann rearrangement reaction, leading to interesting solvent choices.

Item Type:Article
Additional Information:This publication is available on http://www.sciencedirect.com/science/journal/13835866
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Other partners > Sanofi Aventis (FRANCE)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Réaction, mélange & séparation (RMS) - Procédés pour la Chimie Fine
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Procédés Systèmes Industriels (PSI)
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Deposited By:Laurent PRAT

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