OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Optimisation of solvent replacement procedures according to economic and environmental criteria in pharmaceutical industry

Elgue, Sébastien and Cabassud, Michel and Prat, Laurent E. and Cezerac, Jérome Optimisation of solvent replacement procedures according to economic and environmental criteria in pharmaceutical industry. (2006) Chemical Engineering Journal, vol. 1 (n° 2). pp. 169-177. ISSN 1385-8947

[img]
Preview
(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
231kB

Official URL: http://dx.doi.org/10.1016/j.cej.2005.11.017

Abstract

During pharmaceutical syntheses, the reaction solvent has often to be switched off from one reaction step to the following one. Because of the standard industrial practices, solvent replacement generally constitutes a slow and high solvent-consuming operation. In this paper, a specific methodology, based on a batch processes optimisation framework, is proposed for the optimisation of solvent replacement procedures. Optimisation may be performed at different levels according to economic and environmental criteria and satisfying safety and waste treatment constraints. In fact, the proposed methodology allows both to design new procedures of solvent replacement and to improve existing industrial processes. Two industrial applications are detailed to emphasize the benefits related to this methodology. In each case, the proposed methodology leads to the suitable recipe from comparison of traditional and empirical replacement procedures generally used in the pharmaceutical industry.

Item Type:Article
Additional Information:This article is available on http://www.sciencedirect.com/science/journal/13858947
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Other partners > Sanofi Aventis (FRANCE)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Réaction, mélange & séparation (RMS) - Procédés pour la Chimie Fine
Statistics:download
Deposited By: Laurent PRAT

Repository Staff Only: item control page