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TestDose : a SPECT image generator for clinical dosimetry studies

Garcia, Marie-Paule and Der Sarkissian, Henri and Mckay, Erin and Ferrer, Ludovic and Bardiès, Manuel and Villoing, Daphné and Batatia, Hadj and Basarab, Adrian and Tourneret, Jean-Yves and Kouamé, Denis TestDose : a SPECT image generator for clinical dosimetry studies. (2013) In: SPIE Medical Imaging 2013, 9 February 2013 - 14 February 2013 (Orlando, United States).

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Official URL: http://dx.doi.org/10.1117/12.2007840

Abstract

Patient-specific dosimetry in nuclear medicine relies on activity quantification in volumes of interest from scintigraphic imaging. Clinical dosimetry protocols have to be benchmarked against results computed from test phantoms. The design of an adequate model is a crucial step for the validation of image-based activity quantification. We propose a computing platform to automatically generate simulated SPECT images from a dynamic phantom for arbitrary scintigraphic image protocols. As regards the image generation, we first use the open-source NCAT phantom code to generate an anatomical model and 3D activity maps for different source compartments. This information is used as input for an image simulator and each source is modelled separately. Then, a compartmental model is designed, which describes interactions between different functional compartments. As a result, we can derive time-activity curves for each compartment with sampling time determined from real image acqui- sition protocols. Finally, to get an image at a given time after radionuclide injection, the resulting projections are aggregated by scaling the compartment contribution using the specific pharmacokinetics and corrupted by Poisson noise. Our platform consists of many software packages, either in-house developments or open-source codes. In particular, an important part of our work has been to integrate the GATE simulator in our platform, in order to generate automatically the command files needed to run a simulation. Furthermore, some developments were added in the GATE code, to optimize the generation of projections with multiple energy windows in a minimum computation time.

Item Type:Conference or Workshop Item (Paper)
Additional Information:This papers appears in SPIE Proceedings Volume 8668 The definitive version is available at : http://proceedings.spiedigitallibrary.org ; The original PDF is available at: http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1662028
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Other partners > Institut de Cancérologie de L'ouest - ICO (FRANCE)
Laboratory name:
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Deposited By: IRIT IRIT
Deposited On:02 Dec 2015 15:50

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