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Adsorption onto nanocrystalline apatitic calcium phosphates. Applications to growth factors and drugs delivery

Errassifi, Farid and Menbaoui, Anas and Autefage, Hélène and Benaziz, Lhaj and Ouizat, Saadia and Santran, Véronique and Sarda, Stéphanie and Lebugle, Albert and Combes, Christèle and Barroug, Allal and Sfihi, Hocine and Rey, Christian Adsorption onto nanocrystalline apatitic calcium phosphates. Applications to growth factors and drugs delivery. (2010) In: 8th Pacific Rim Conference on Ceramics and Glass Technology (PACRIM-8), 31 May 2009 - 31 June 2009 (Vancouver, Canada).

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Abstract

Interfacial properties of apatitic calcium phosphate play a crucial role in calcified tissues and biomaterials. Generally the adsorption of molecules on apatitic calcium phosphates is considered to obey to electrostatic interactions. The study of the adsorption of various active molecules such as albumin, heparin, bisphosphonate, and growth factors like BMP-2, VEGF and FGF-2 on such surfaces seems to follow a similar pathway. In all cases the adsorption process can be well described using Langmuir isotherms, although the adsorption process appears generally as irreversible. Further studies of the adsorption reaction reveal, in most cases, an ion exchange mechanism involving the replacement of mineral ions of the apatite surface by molecular ions from the solution. Considering biomimetic apatite nanocrystals, considerable variations of the adsorption parameters are observed depending on the maturation time of the nanocrystals. As the maturation time increases, the adsorption affinity constant increases and the maximum amount adsorbed decreases. The understanding of the adsorption process provides fundamental tools for the development of drug delivery system using apatite materials. Applications to the release of active molecules are examined in the case of apatite coatings.

Item Type:Conference or Workshop Item (Paper)
Additional Information:Thanks to Wiley Editor. This paper appears in Ceramics for Environmental and Energy Applications: Ceramic Transactions, Volume 217, Aldo R. Boccaccini (Editor), Mrityunjay Singh (Editor), James Marra (Editor), Fatih Dogan (Editor), Hua-Tay Lin (Editor), Toshiya Watanabe (Editor), ISBN: 978-0-470-90547-0, 186 pages, August 2010.
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > University of Cadi Ayyad - UCAM (MOROCCO)
Other partners > Ecole supérieure de physique et de chimie industrielles ParisTech - ESPCI (FRANCE)
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Deposited By: cirimat webmestre
Deposited On:22 Oct 2014 08:01

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