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Infrared, Raman and NMR investigations of risedronate adsorption on nanocrystalline apatites

Errassifi, Farid and Sarda, Stéphanie and Barroug, Allal and Legrouri, Ahmed and Sfihi, Hocine and Rey, Christian Infrared, Raman and NMR investigations of risedronate adsorption on nanocrystalline apatites. (2014) Journal of Colloid and Interface Science, 420. 101-111. ISSN 0021-9797

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Official URL: http://dx.doi.org/10.1016/j.jcis.2014.01.017

Abstract

The aim of the current work was to study the physico-chemical interactions of a bisphosphonate molecule, risedronate, with a well-characterised synthetic nanocrystalline apatite (NCA) as a model bone mineral. We adopted a global approach, using complementary physico-chemical techniques such as FTIR,RAMAN and NMR spectroscopies in order to learn more about the interaction process of risedronate with the apatitic surface. The results obtained suggest that risedronate adsorption corresponds to an ion substitution reaction with phosphate ions occurring at the crystal surface. This mechanism explains the greater amount adsorbed (N) for NCA, compared to well crystallised stoichiometric hydroxyapatite, attributable to the well-developed hydrated layer at the surface of the nanocrystals. However, most calcium ions remain attached to the solid phase and the formation of insoluble risedronate calcium salts must also be considered as a competitive reaction to the adsorption. Thus a calcium risedronate salt was synthesised and fully characterised for comparison to the solids after adsorption. Following spectroscopic results, it can be concluded that a strong interaction was established between risedronate ions and calcium ions at the apatitic surface. However, under these experimental conditions there is no nucleation of a distinct calcium risedronate salt and the apatite crystals retain their integrity.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Journal of Colloid and Interface Science website : http://www.sciencedirect.com/science/article/pii/S0021979714000253
HAL Id:hal-01092765
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Al Akhawayn University - AUI (MOROCCO)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Other partners > Université Pierre et Marie Curie, Paris 6 - UPMC (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > University of Cadi Ayyad - UCAM (MOROCCO)
Other partners > Ecole supérieure de physique et de chimie industrielles ParisTech - ESPCI (FRANCE)
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Deposited By: cirimat webmestre
Deposited On:16 Oct 2014 10:30

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