OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Kinetic modeling in the context of cerebral blood flow quantification by H215O positron emission tomography: The meaning of the permeability coefficient in Renkin–Crone׳s model revisited at capillary scale

Lorthois, Sylvie and Duru, Paul and Billanou, Ian and Quintard, Michel and Celsis, Pierre Kinetic modeling in the context of cerebral blood flow quantification by H215O positron emission tomography: The meaning of the permeability coefficient in Renkin–Crone׳s model revisited at capillary scale. (2014) Journal of Theoretical Biology, 353. 157-169. ISSN 0022-5193

[img]
Preview
(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
675kB

Official URL: http://dx.doi.org/10.1016/j.jtbi.2014.03.004

Abstract

One the one hand, capillary permeability to water is a well-defined concept in microvascular physiology, and linearly relates the net convective or diffusive mass fluxes (by unit area) to the differences in pressure or concentration, respectively, that drive them through the vessel wall. On the other hand, the permeability coefficient is a central parameter introduced when modeling diffusible tracers transfer from blood vessels to tissue in the framework of compartmental models, in such a way that it is implicitly considered as being identical to the capillary permeability. Despite their simplifying assumptions, such models are at the basis of blood flow quantification by H215O Positron Emission Tomography. In the present paper, we use fluid dynamic modeling to compute the transfers of H215O between the blood and brain parenchyma at capillary scale. The analysis of the so-obtained kinetic data by the Renkin-Crone model, the archetypal compartmental model, demonstrates that, in this framework, the permeability coefficient is highly dependent on both flow rate and capillary radius, contrarily to the central hypothesis of the model which states that it is a physiological constant. Thus, the permeability coefficient in Renkin-Crone's model is not conceptually identical to the physiologic permeability as implicitly stated in the model. If a permeability coefficient is nevertheless arbitrarily chosen in the computed range, the flow rate determined by the Renkin-Crone model can take highly inaccurate quantitative values. The reasons for this failure of compartmental approaches in the framework of brain blood flow quantification are discussed, highlighting the need for a novel approach enabling to fully exploit the wealth of information available from PET data.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com/science/article/pii/S0022519314001398
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Laboratory name:
Funders:
Pierre Fabre Dermocosmetique - Région Midi Pyrénées
Statistics:download
Deposited By: Sylvie LORTHOIS
Deposited On:07 Apr 2014 09:54

Repository Staff Only: item control page