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Metabolic Fate of 2,4-Dichlorophenol and Related Plant Residues in Rats

Pascal-Lorber, Sophie and Despoux, Sabrina and Jamin, Emilien and Canlet, Cécile and Cravedi, Jean-Pierre and Laurent, François Metabolic Fate of 2,4-Dichlorophenol and Related Plant Residues in Rats. (2012) Journal of Agricultural and Food Chemistry, 60 (7). 1728-1736. ISSN 0021-8561

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Official URL: http://dx.doi.org/10.1021/jf203666k

Abstract

This study compared the metabolic fate of [14C]-DCP, [14C]-residues from radish plants, and purified [14C]-DCP-(acetyl)glucose following oral administration in rats. A rapid excretion of radioactivity in urine occurred for [14C]-DCP, [14C]-DCP-(acetyl)glucose, and soluble residues, 69, 85, and 69% within 48 h, respectively. Radio-HPLC profiles of 0−24 h urine from rats fed [14C]-DCP and [14C]-DCP-(acetyl)glucose were close and qualitatively similar to those obtained from plant residues. No trace of native plant residues was detected under the study conditions. The structures of the two major peaks were identified by MS as the glucuronide and the sulfate conjugates of DCP. The characterization of a dehydrated glucuronide conjugate by MS and NMR of DCP was unusual. In contrast to soluble residues, bound residues were mainly excreted in feces, 90% within 48 h, whereas total residues were eliminated in both urine and feces. For total residues, the radioactivity in feces was higher than expected from the percentage of soluble and bound residues in radish plants. This result highlighted that less absorption took place when residues were present in the plant matrix as compared to plant-free residues and DCP.

Item Type:Article
Additional Information:Thanks to American Chemical Society editor. The original PDF of the article can be found at Journal of Agricultural and Food Chemistry website : http://pubs.acs.org/journal/jafcau
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
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Deposited By: Sophie Lorber
Deposited On:04 Mar 2014 08:01

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